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Dethiobiotin synthetase

Biotin synthase (BioB) (EC 2.8.1.6) is an enzyme that catalyzes the conversion of dethiobiotin (DTB) to biotin; this is the final step in the biotin biosynthetic pathway. Biotin, also known as vitamin B7, is a cofactor used in carboxylation, decarboxylation, and transcarboxylation reactions in many organisms including humans. Biotin synthase is an S-Adenosylmethionine (SAM) dependent enzym… WebNov 1, 2000 · Sequence analysis of this fragment revealed that it is closely related to a family of ATP-dependent enzymes that also includes dethiobiotin synthetase and the synthetase domains of two amidotransferases involved in cobalamin biosynthesis, cobyrinic acid a,c-diamide synthase (CobB) and cobyric acid synthase (CobQ).

Structural characterization of Helicobacter pylori dethiobiotin ...

WebProtein target information for Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial (thale cress). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. WebAug 31, 1998 · The crystal structures of two complexes of dethiobiotin synthetase, enzyme-diaminopelargonic acid-MgADP-AlF3 and enzyme-dethiobiotin-MgADP-Pi, respectively, have been determined to 1.8 A … ty alexander instagram https://multiagro.org

[61] Dethiobiotin synthetase - ScienceDirect

WebMar 9, 2024 · Dethiobiotin synthetase catalyzes the first ring closure in the biosynthesis of biotin, which is the penultimate step in the biosynthesis pathway. [More information is available at EcoCyc: EG10120]. Other designations dethiobiotin synthetase GeneRIFs: Gene References Into Functions N-terminus verified by Edman degradation on mature … WebThe creative, dynamic city is so popular, in fact, National Geographic selected Atlanta as one of the top destinations to visit in the National Geographic Best of the World 2024 list, … WebMar 28, 1995 · One of these enzymes, ATP-dependent dethiobiotin synthetase, catalyzes the carboxylation of 7,8-diaminopelargonic acid leading to the formation of the ureido ring of biotin. The enzyme belongs to the class of ATP-dependent carboxylases and we present here the first crystal structure determined for this class of enzyme. tammy hatcher

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Category:Dethiobiotin synthetase: the carbonylation of 7,8 ... - PubMed

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Dethiobiotin synthetase

Dethiobiotin: Uses, Interactions, Mechanism of Action - DrugBank

WebJan 1, 1979 · This chapter presents an overview of dethiobiotin (DTB) synthetase. The interrelationship between 7,8-diaminopelargonic acid and DTB has been first established … WebThe levels of dethiobiotin synthetase in Escherichia co2i have been increased 6-fold over the wild type when pre- pared from a X-lysogen carrying the bioD gene under phage …

Dethiobiotin synthetase

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WebThis article is cited by 32 publications. Andrew P. Thompson, Wanisa Salaemae, Jordan L. Pederick, Andrew D. Abell, Grant W. Booker, John B. Bruning, Kate L. Wegener, Steven W. Polyak. Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes. WebMay 8, 1995 · 1DAD, 1DAE, 1DAF, 1DAG, 1DAH, 1DAI. PubMed Abstract: The crystal structures of six complexes of homodimeric Escherichia coli dethiobiotin synthetase with a variety of substrates, substrate analogs, …

WebPubMed WebProtein target information for Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial (thale cress). Find diseases associated with this …

WebSpecifically, DTBS allows for the ATP-dependent formation of dethiobiotin from 7,8-diaminopelargonic acid (DAPA) and CO 2 by catalyzing a ureido ring formation(4). The … WebOct 15, 1998 · The crystal structure of the 224-residue protein dethiobiotin synthetase from Escherichia coli has been refined using X-ray diffraction data at 0.97 A resolution at 100 K. The model, consisting of 4143 protein atoms including 1859 H atoms and 436 solvent sites, was refined to a final R factor of 11 ... Macromolecules

WebMar 31, 1998 · The ATP-dependent enzyme dethiobiotin synthetase from Escherichia coli catalyses the formation of dethiobiotin from CO2 and 7, 8-diaminopelargonic acid. The …

WebDethiobiotin synthetase, DTBS, (PDB id = 1a82) plays an important role in the biotin synthetic pathway. Better known as vitamin H, all organisms require biotin. Biotin’s necessity for life lies in its identity as a prosthetic group for the enzymes that catalyze the many biological carboxylation and transcarboxylation reactions (1). tyalo softwareWebIn addition, the synthetase domain is homologous to dethiobiotin synthase, 198 an enzyme that forms an iminophosphate intermediate during catalytic turnover. 199 The … ty alto\u0027sWebThe levels of dethiobiotin synthetase in Escherichia co2i have been increased 6-fold over the wild type when pre- pared from a X-lysogen carrying the bioD gene under phage control. The purification procedure employed gave a nearly … tammy hausbootWebD-Desthiobiotin. (Synonyms: Dethiobiotin) Cat. No.: HY-128699 Purity: 98.19%. COA Handling Instructions. D-Desthiobiotin is a biotin derivative used in affinity … tammy hawkins facebookWebApr 17, 2024 · The ureido ring of dethiobiotin is formed by the enzyme dethiobiotin synthase (DTBS). The final step involves the insertion of sulfur and is catalyzed by the enzyme biotin synthase (BS). tyalor hurley stabbed in school busWebDethiobiotin synthetase. Dethiobiotin synthetase. Dethiobiotin synthetase Methods Enzymol. 1979;62:348-52. doi: 10.1016/0076-6879(79)62241-3. Authors M A Eisenberg, … tammy hatfield boise idahoWebJun 13, 2005 · Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. Gene Name bioB Uniprot … ty alteration\u0027s